基本信息

 

 



 王一理,医学博士,病理学教授,博士生导师,基础医学院癌症研究所所长。《中华肿瘤杂志》、《中华病理学杂志》编委。 1982年毕业于原西安医学院医疗系,1986-1990年美国匹兹堡大学癌症研究所博士后。 研究方向为肿瘤免疫,分子病理。主要从事肿瘤免疫基础理论和应用以及人乳头瘤病毒预防性疫苗研究。原位分析肿瘤微环境中免疫细胞与肿瘤细胞相互作用及其临床意义,受邀参与SITC组织的大肠癌免疫分型全球工作组;提出以减毒志贺菌为载体的口服HPV预防性疫苗策略,取得有意义的结果。主持多项国家及省部级科研课题,发表多篇学术论文。《人乳头瘤病毒预防性疫苗研制策略及其免疫生物学研究》获陕西省科技进步二等奖,《肿瘤局部免疫反应特征原位研究》获卫生部科技进步三等奖。获西安医科大学病理学科跨世纪学术与技术带头人称号(96年西安医大人才工程证字001号)。 1996年享受国务院政府特殊津贴(政府特殊津贴(96)3610031号)

 

 

联系方式

通讯地址: 西安交通大学 医学校区癌症研究所 
西安市南郊雁塔西路76号  710061
电话   (029 )82655499(办), 
电传  (029 )82655499
Email   wangyili@mail.xjtu.edu.cn
          

工作经历

1990.6-2000.4 西安医科大学免疫病理研究室
1993.9               破格晋升副教授(副研究员)
1995.9               破格晋升教授(研究员)
1996.4               经卫生部学位办批准为博士生导师
1997.3               免疫病理研究室主任
2000.4-2000.12 西安交通大学医学院
2000.10-12       西安交通大学医学院基础部主任

2001.2-5           英国帝国理工大学Ludwig 研究所高级访问学者
2000.12-2013   西安交通大学生命科学与技术学院副院长 癌症研究所所长

2014.---            西安交通大学基础医学院癌症研究所 所长
 

教育经历

1978.2-1982.12   原西安医学院医学系 学士
1983.1-1985.12   原西安医学院病理学教研室 硕士
1986.1-1986.10    原西安医学院病理学教研室助教
1986.11-1990.5    美国匹兹堡大学癌症研究所博士后

1995.--1998.7      西安医科大学免疫病理研究室 博士

文章专著

 

发表论文与专著

 

专著
 
1、 参编《分子病毒学》面向21世纪课程教材(研究生用), 黄文林主编,人民卫生出版社 2002.8 第一版 ISBN7-117-04841-7  
2、  参编  《中华外科病理学》 武忠弼  杨光华 主编, 人民卫生出版社 2002年 第一版
3、  参编《分子病毒学》面向21世纪课程教材(研究生用), 黄文林主编,人民卫生出版社  2005年 第二版
4、 参编 《细胞工程》 普通高等教育“十五”国家及规划教材,陈志南主编,科学出版社,2005 第一版ISBN 7-03-015147 

5、参编 《病理学》 国家卫生和计划生育委员会十二五规划教材,全国高等医药教材建设研究会十二五规划教材,来茂德主编, 人民卫生出版社,2014ISBN 978-7-117-19598-0/R.19599

6、参编 《中华医学百科全书》-《基础医学-病理学》 陈杰主编,中国协和医科大学出版社 2021.1ISBN-978-7-56791587-9

7、参编 《病理学名词》陈杰主编,科学出版社,2020.9 ISBN 978-7-03-066077-0

 

论文:

 

1、王一理  袁定东  T淋巴细胞亚群与癌细胞相互作用的原位免疫电镜观察  西安医科大学学报  1987, 8(1):32-35

2、Si Lusheng, Wang Yili and Zhang YunJing   Infiltrating T lymphocyte activity in gastric and colonic cancer and early deciduas. Chinese Medical Journal, 1987,10012:961-964

3、Theresa L. Whiteside, YiLi Wang, Robert G. Selke, and Ronald B. Herberman   In vitro generation and antitumor activity of adherent lymphokine activated killer cells from the blood of patients with brain tumor. Cancer Res. 1988,48:6069

4、Wang YiLi, Si Lusheng, Anisa Kanbour, Ronald B. Herberman and Theresa L. Whiteside Lymphocytes infiltrating human ovarian tumor: synergy between tumor necrosis factor and interleukin 2 in the generation of CD8+ effectors from tumor infiltrating lymphocytes.   Cancer Res.   1989,4921:5979

5、Luis Vaccarello, YiLi Wang and Theresa L. Whiteside   Sustained outgrowth of autotumor-reactive T lymphocytes from human ovrarian carcinomas in the presence of tumor necrosis factor and interleukin2.  Human Immunology. 1990,28:216-227

 

6、Jin Zheng, Lusheng Si, Jianming Song, Xiangle Sun,Jun Yu and Yili Wang Enhanced Immune response to DNA-based HPV16L1 vaccination by costimulatory molecule B7-2 Antiviral Research 2003, 59:61-65 (SCI)

 

7、Xiaofeng Yang Xinzhong QuKai Wang, Jin Zheng, Lusheng Si, Xiaoping Dong and YiLi Wang. Construction of Prophylactic Human Papillomavirus Type 16 L1 Caspid Protein Vaccine Delivered by Attenuated Shigella Flexneri Strain sh42  Acta Biochimica et Biophysica Sinica 2005, 37(11):743-750(SCI)

  

8、Zhang Ying-Tao, Geng Yi-Ping, Si Lu-Sheng and Wang Yi-Li Proteomic analysis of differentially expressed proteins between metastatic and non-metastatic human colorectal carcinoma cell lines  European Journal of Gastroenterology & Hepatology 2005, 177):725-732  

9、Le Zhou, Yan Wang, Ying-tao Zhang,Yi-ping Geng, Lusheng Si, Yi-li Wang  Proteomics-based analysis of a pair of glioma cell lines with different tumor forming characteristics Neuroscience Letters 401 (2006) 59–64

 

10、Walayat Shah, Chen Hongwei, Zheng Jin, Dong Lifang, Yu Jun, Wang Yili The Prevalence of Human Papillomavirus Type 58 in Chinese Patients with Cervical Carcinoma and its Influence on Survival  Clinical Oncology (2009) 21: 768-774

 

11、Xiaofei Yan,  Walayat Shah,  Xu Li , Yili Wang   Estrogen contributes to non-pRb targeted HPV18 E7-caused cell proliferation and transformation  Cancer Biology & Therapy 9(3): 206 – 215, 2010

  

12、Walayat Shah Xiaofei Yan , Li Jing , Yi Zhou , Hongwei Chen and Yili Wang  A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4 FOXP3 regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix Cellular & Molecular Immunology (2010), Cellular & Molecular Immunology (2010), 81):59-66

 

13、王鸿雁,何建军,史秦峰,来宝长,丁海燕,郑瑾,王一理   乳腺癌原发灶及腋窝淋巴结中细胞毒性淋巴细胞与临床病理的关系   中华病理学杂志   2009, 38(6):384-388

14、王鸿雁,史秦峰,孙颖,何建军,王一理 人乳腺癌组织及局部引流淋巴结中调节性T细胞分析   中华病理学杂志2013 42(2):95-100

15、Dan Xu, Depu Wang, Xiaofeng Yang, Meng Cao, Jun Yu, Yili Wang  Fusion of HPV L1 into Shigella surface IcsA: A new approach in developing live attenuated Shigella-HPV vaccine Antiviral Research 2014, 102: 61–69

16、Yan Wang, Le Zhou, Hongyan Wang, Juxiang Xiao,Lusheng Si and Yili Wang          The ex vivo Microenvironments in MLTC of Poorly Immunogenic Tumor Cells Facilitate Polarization of CD4+CD25+ Regulatory T Cells   Cellular & Molecular Immunology 2006, 3(2):123-129

17、张晨华,许丹,王一理  经直肠豚鼠志贺菌痢疾模型的改良 西安交通大学学报(医学版), 2011,32(2):258-260

18、Shi Qinfeng,  Wang Depu,  Yang Xiaofeng,  Walayat Shah,  Chen Hongwei  and Wang Yili , In Situ Observation of the Effects of Local Irradiation on Cytotoxic and Regulatory T Lymphocytes in Cervical Cancer Tissue RADIATION RESEARCH  (2013) 179, 584–589

19、Immunoscore Worldwide Task Force:    Cancer classification using the Immunoscore: a worldwide task force  J Transl Med. 2012,10:205. doi: 10.1186/1479-5876-10-205

20、Immunoscore Worldwide Task Force:   Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumors  J Pathol 2014; 232: 199–209

21、Immunoscore Worldwide Task Force: International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy studyLancet2018391(10135):2128-2139

22、Immunoscore Worldwide Task Force Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer J Clin Oncol. 2020 Nov 1;38(31):3638-3651

23、Meng Cao,  Ying Wang, Depu Wang, Yixin Duan, Wei Hong, Nana Zhang,  Walayat Shah, Yili Wang,  and Hongwei Chen,  Increased High-Risk Human Papillomavirus Viral Load Is Associated With Immuno-suppressed Microenvironment and Predicts a Worse Long-Term Survival in Cervical Cancer Patients  Am J Clin Pathol  2020;153:502-512

24、Yixin Duan, Haixia Bai, Xiang Li , Depu Wang , Ying Wang , Meng Cao, Nana Zhang, Hongwei Chen and Yili Wang  Oncolytic Adenovirus H101 Synergizes with Radiation in Cervical Cancer Cells  Current Cancer Drug Targets, 202121619-630